Systemic endothelium damage and its functional consequences under the action of injuries and infectious agents

Topicality: Blockage of hemorrhage due to vascular damage is the leading role clotting cascade hemostasis system. Recently, two types such have become highly relevant. The first them caused by viral endothelium, which leads uncontrolled activation descending second type aquabarotrauma and associated hydrodynamic shock. Both lead development thrombotic-fibrous complications circulatory system formation long fibrin deposits. Such deposits are resistant action fibrinolytic their irregular chaotic structure. This, in turn, severe functional complications. Aim: Systematize data on molecular cellular features systemic endothelium. To compare clinical material persons who suffered from or died COVID-19. disorders hearing organs experienced akubarotrauma ill with Results discussion: COVID-19 as a result it presented. acubarotrauma considered. reasons for resistance vessels systemically damaged endothelium discussed. Possible methodical approaches overcoming considered